In the last several decades there have been major improvements in the abili
ty to control fertility, treat infertility, and reduce maternal, fetal, and
infant mortality. However, neither the preterm birth rate nor the rate of
long-term neurologic disabilities associated with preterm birth has decline
d. Increasing knowledge of the events leading to preterm birth and the path
ophysiology of neonatal brain and lung injury suggests that the mortality a
nd longterm impairments associated with these conditions will decrease. The
large disparities in reproductive health and birth outcomes between indust
rialized and developing countries and between most other ethnic groups and
blacks in the United States could be reduced by better access to already ex
isting effective interventions.