Y. Teranishi et al., Is compensatory vasoconstrictor tone in the hindquarter vascular region induced by hemorrhage in conscious spontaneously hypertensive rats?, JPN J PHARM, 85(1), 2001, pp. 109-113
We investigated whether a compensatory vasoconstrictor action would be indu
ced by a hypotensive intervention in the hindquarter vascular region of con
scious spontaneously hypertensive rats (SHRs). Mean arterial pressure and h
indquarter blood flow were recorded. After hemorrhage (withdrawing blood, 0
.3 ml/100 g body weight), hindquarter resistance (HQR) was increased signif
icantly. The decrease in HQR induced by the administration of a ganglionic
blocker (C6; 25 mg/kg, i.v.) was significantly greater in SHRs with hemorrh
age than in those without hemorrhage. The present results suggest that a de
tectable hindquarter compensator tone occurs due to hemorrhage in SHRs, alt
hough an abnormal substantial vasoconstrictor tone already exists in the hi
ndquarters.