J. Minami et al., Effect of a hypocaloric diet on adrenomedullin and natriuretic peptides inobese patients with essential hypertension, J CARDIO PH, 36(6), 2000, pp. S83-S86
Citations number
17
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
We examined the effect of a hypocaloric diet on adrenomedullin (AM), atrial
natriuretic peptide (ANP), and brain natriuretic peptide (BNP) in 12 obese
patients with essential hypertension (ag, 48-81 years; body mass index, 26
-34 kg/m(2)). For the initial week, a standard diet of 2000 kcal/day was gi
ven, followed by 3 weeks of a hypocaloric diet of 850 kcal/day, with a cons
tant intake of sodium. The patients lost 3.7 +/- 0.2 kg body weight during
the hypocaloric diet period (p < 0.0001). The decrease in blood pressure du
ring the study period was 10.3 +/- 3.6 mmHg systole (p = 0.017) and 4.2 +/-
3.2 mmHg diastole (NS). Plasma AM concentration was decreased significantl
y from 4.88 +/- 0.46 to 3.97 +/- 0.38 pmol/l by the hypocaloric diet (p = 0
.004). Plasma ANP and BNP concentrations were also decreased sinificantly b
y the hypocaloric diet (p = 0.042 for each). These results demonstrate, for
the first time, that plasma AM concentration as well as plasma ANP and BNP
concentrations are decreased by a hypocaloric diet in obese patients with
essential hypertension. These vasodilator peptides may act against further
elevation in blood pressure in obese patients with essential hypertension.