Effect of a hypocaloric diet on adrenomedullin and natriuretic peptides inobese patients with essential hypertension

Citation
J. Minami et al., Effect of a hypocaloric diet on adrenomedullin and natriuretic peptides inobese patients with essential hypertension, J CARDIO PH, 36(6), 2000, pp. S83-S86
Citations number
17
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
ISSN journal
01602446 → ACNP
Volume
36
Issue
6
Year of publication
2000
Supplement
2
Pages
S83 - S86
Database
ISI
SICI code
0160-2446(2000)36:6<S83:EOAHDO>2.0.ZU;2-E
Abstract
We examined the effect of a hypocaloric diet on adrenomedullin (AM), atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP) in 12 obese patients with essential hypertension (ag, 48-81 years; body mass index, 26 -34 kg/m(2)). For the initial week, a standard diet of 2000 kcal/day was gi ven, followed by 3 weeks of a hypocaloric diet of 850 kcal/day, with a cons tant intake of sodium. The patients lost 3.7 +/- 0.2 kg body weight during the hypocaloric diet period (p < 0.0001). The decrease in blood pressure du ring the study period was 10.3 +/- 3.6 mmHg systole (p = 0.017) and 4.2 +/- 3.2 mmHg diastole (NS). Plasma AM concentration was decreased significantl y from 4.88 +/- 0.46 to 3.97 +/- 0.38 pmol/l by the hypocaloric diet (p = 0 .004). Plasma ANP and BNP concentrations were also decreased sinificantly b y the hypocaloric diet (p = 0.042 for each). These results demonstrate, for the first time, that plasma AM concentration as well as plasma ANP and BNP concentrations are decreased by a hypocaloric diet in obese patients with essential hypertension. These vasodilator peptides may act against further elevation in blood pressure in obese patients with essential hypertension.