Simple regioselective synthesis of spiro[2H-indene-2,3 '-[3H]pyrazoles]

Authors
Girgis, AS Ibrahim, YA Farag, ISA Mishriky, N
Citation
As. Girgis et al., Simple regioselective synthesis of spiro[2H-indene-2,3 '-[3H]pyrazoles], J CHEM R-S, (11), 2000, pp. 508-509
Citations number
8
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF CHEMICAL RESEARCH-S
ISSN journal
03082342 → ACNP
Issue
11
Year of publication
2000
Pages
508 - 509
Database
ISI
SICI code
0308-2342(200011):11<508:SRSOS'>2.0.ZU;2-S
Abstract
1,3-Dipolar cycloaddition of nitrilimines to a variety of 2-arylmethylidene -1-indanones 1 or 2-arylmethylidene-1,3-indandiones 5 gave the correspondin g spiro[2H-indene-2,3'-[3H]pyrazol]-1(3H)-one 3 and their 1,3-dione derivat ives 6 in high regioselectivity. The stereo-configuration of 3 (3'R, 4'S or its enantiomeric form) was established by nOe-difference technique as well as single crystal X-ray diffraction analysis.