Separation of enantiomers by gas chromatography

The separation of enantiomers by gas chromatography is performed on chiral stationary phases (CSPs) via hydrogen bonding, coordination and inclusion. Thus, typical chiral selectors are amino acid derivatives, terpene-derived metal coordination compounds and modified cyclodextrins. In Chirasil-type s tationary phases the chiral selector is anchored to a polysiloxane backbone improving gas chromatographic performance. The present review article desc ribes the state-of-the-art, scope and limitations, applications and mechani stic considerations at the advent of the millennium incorporating 16 figure s and 168 references. (C) 2001 Elsevier Science B.V. All rights reserved.