Background: Risperidone is an "atypical" antipsychotic with strong binding
affinity for dopamine-2 and serotonin-2 receptors. Risperidone is often use
d to treat hospitalized patients who have acute psychotic decompensation, a
nd the therapeutic target dose commonly used is 2 to 6 mg/day. The most com
mon clinical practice is to titrate the dose of risperidone to the target t
herapeutic dose over several days. This study investigated the safety and t
olerability of a rapid oral-loading regimen for risperidone developed to ac
hieve therapeutic doses of this antipsychotic within 24 hours.
Method: Rapid-loaded risperidone was initiated with 1 mg. Subsequent doses
were increased by 1 mg every 6 to 8 hours up to 3 mg. Dose increases were c
ontingent on tolerance of last administered dose.
Results: Of a sample of 11 consecutive inpatients admitted to an acute psyc
hiatric facility who were treated with this protocol, 7 tolerated the most
rapid titration, achieving a standing dose of 3 mg b.i.d. in 16 hours. Thre
e required a slightly slower titration and achieved this target dose in 24
hours. One patient could not tolerate the 3-mg dose but tolerated a standin
g regimen of 2 mg t.i.d. No patient experienced serious extrapyramidal side
effects, sedation, or any other adverse event during the rapid titration,
and in no case did risperidone have to be discontinued.
Conclusion: These results suggest that aggressive dosing of risperidone is
well tolerated in most psychiatric inpatients.