Novel single nucleotide polymorphisms of the human nuclear factor kappa-B 2 gene identified by sequencing the entire gene

The nuclear factor kappa-B 2 (NFKB2) gene is a member of the NFKB/Rel gene family, which is known to be a pivotal regulator of the acute phase of the inflammatory response and of immune responses. We identified three novel si ngle nucleotide polymorphisms (SNPs) and determined their allelic frequenci es, as determined by the sequencing of 48 alleles of the entire: gene in a Japanese population sample. Two Of the three polymorphisms were identified at nucleotide (nt) position 1837 (T/C) and nt position. 1867 (GG/G) in the upstream region of the gene. The other polymorphism was identified at nt po sition 2584 (G/T) within intron 1. These polymorphisms will be useful in ge netic studies of the processes involved in inflammatory responses and in bo ne differentiation.