UP-REGULATION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) REPLICATION BY CD4 CROSS-LINKING IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF HIV-INFECTED ADULTS

Authors
THAN S OYAIZU N TETALI S ROMANO J KAPLAN M PAHWA S
Citation
S. Than et al., UP-REGULATION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) REPLICATION BY CD4 CROSS-LINKING IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF HIV-INFECTED ADULTS, Journal of virology, 71(8), 1997, pp. 6230-6232
Citations number
17
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
71
Issue
8
Year of publication
1997
Pages
6230 - 6232
Database
ISI
SICI code
0022-538X(1997)71:8<6230:UOH(RB>2.0.ZU;2-J
Abstract
This study was conducted with peripheral blood mononuclear cells from 67 human immunodeficiency virus (HIV)-infected adults. It supports the hypothesis that cross-linking of CD4 molecules by HIV gp120 can resul t in HIV upregulation and spread of infection, Underlying mechanisms i nclude activation of latent infection by factors in addition to, or ot her than, tumor necrosis factor alpha.