Fl. Conceicao et al., Evidence-based approach to growth hormone replacement therapy in adults, with special emphasis on body composition, J PED END M, 13, 2000, pp. 1353-1358
In the past decade, a large number of controlled clinical trials have repor
ted positive effects of growth hormone (CH) replacement therapy in GH-defic
ient adults. The majority of these studies have been carried out in accorda
nce with the guidelines for Good Clinical Practice. The data thus accumulat
ed offer a solid baseline for practicing evidence-based medicine within thi
s area of endocrinology.