Recombinant human lactoferrin is effective in the treatment of Helicobacter felis-infected mice

Recombinant human lactoferrin possesses in-vitro antibiotic and anti-inflam matory activity similar to the native form. It was tested for in-vivo activ ity in mice infected with the gastritis-inducing bacterium Helicobacter fel is. A two-week course of treatment with lactoferrin was sufficient to partially reverse both infection-induced gastritis and the infection rate, and fully reverse gastric surface hydrophobicity changes. A comparison of lactoferri n with amoxicillin and standard triple therapy revealed no differences in i nfection rate. These results show that recombinant human lactoferrin is effective in a mou se model of Helicobacter infection, and support further testing of this pro mising agent for this application.