Cross-coupling reactions in Cinchona alkaloid chemistry: aryl-substituted and dimeric quinine, quinidine, as well as quincorine and quincoridine derivatives

Authors
Frackenpohl, J Braje, WM Hoffmann, HMR
Citation
J. Frackenpohl et al., Cross-coupling reactions in Cinchona alkaloid chemistry: aryl-substituted and dimeric quinine, quinidine, as well as quincorine and quincoridine derivatives, J CHEM S P1, (1), 2001, pp. 47-65
Citations number
60
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14727781 → ACNP
Issue
1
Year of publication
2001
Pages
47 - 65
Database
ISI
SICI code
1472-7781(20010107):1<47:CRICAC>2.0.ZU;2-N
Abstract
Cross-coupling reactions of modified Cinchona alkaloids provide access to a wide variety of novel arylated and dimeric derivatives of quinine and quin idine containing a single and double 1,2-amino alcohol functionality. Sonog ashira and Heck reactions allow functionalization of ethynyl and 11-iodovin yl precursors. The role of bystander functionality is investigated.