Parasite glycoconjugates. Part 11. Preparation of phosphodisaccharide synthetic probes, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania

Authors
Ross, AJ Ivanova, IA Ferguson, MAJ Nikolaev, AV
Citation
Aj. Ross et al., Parasite glycoconjugates. Part 11. Preparation of phosphodisaccharide synthetic probes, substrate analogues for the elongating alpha-D-mannopyranosylphosphate transferase in the Leishmania, J CHEM S P1, (1), 2001, pp. 72-81
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14727781 → ACNP
Issue
1
Year of publication
2001
Pages
72 - 81
Database
ISI
SICI code
1472-7781(20010107):1<72:PGP1PO>2.0.ZU;2-E
Abstract
A set of phosphodisaccharides, substrate analogues, which will be used to s tudy acceptor-substrate specificity of the Leishmania biosynthetic enzymes, are synthesized using the Koenigs-Knorr and trichloroacetimidate methods f or the glycosylation reactions, S(N)2 nucleophilic displacement of a trifli c ester for epimerization, and the glycosyl hydrogenphosphonate method for phosphorylation.