Microstructural characterization and in vitro apatite formation in CaO-P2O5-TiO2-MgO-Na2O glass-ceramics

Bulk calcium phosphate glass and glass-ceramic with CaO/P2O5 molar ratio = 1.25 were prepared through introducing small amounts of Na2O, MgO, and TiO2 into the glass. Using XRD analysis, biocompatible beta -Ca2P2O7 (beta -DCP ) and more soluble Ca and Na-containing phases were clearly identified in t he microstructure. In vitro bioactivity was assessed by immersion testing i n SBF-simulated body fluid and apatite crystals were formed after 4 and 8 w eeks of soaking. Porous microstructure was produced through dissolution of soluble phases and desirable porous structure may be achieved by controllin g size and distribution of these phases and the leaching process. Therefore , this glass-ceramic is expected to be used as bone repair and regeneration implants and drug delivery carrier. (C) 2001 Elsevier Science Ltd. All rig hts reserved.