M. Courregelongue et al., Interactions between antiviral prostaglandins and biomimetic membranes. A Langmuir films study, J THERM ANA, 63(1), 2000, pp. 47-57
Cyclopentenonic derivatives of prostaglandins are able to interfere at diff
erent levels with virus infection but the complex mechanism of their antivi
ral effect is still unresolved. As the antiviral activity was shown to be i
nfluenced by the cyclopentenonic structure, the interaction with biomimetic
membrane of two types of prostaglandin having different antiviral activity
were studied by thermal technique and completed with epifluorescence micro
scopy. The surface-pressure vs. molecular area isotherms showed an increase
in the lateral packing density of the liquid-crystalline phases in the pre
sence of prostaglandin A(1)-type, whereas the prostaglandin E-1-type seems
to penetrate without producing any significant modifications in the molecul
ar organization of the biomimetic membrane.