Interactions between antiviral prostaglandins and biomimetic membranes. A Langmuir films study

Citation
M. Courregelongue et al., Interactions between antiviral prostaglandins and biomimetic membranes. A Langmuir films study, J THERM ANA, 63(1), 2000, pp. 47-57
Citations number
24
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
ISSN journal
13886150 → ACNP
Volume
63
Issue
1
Year of publication
2000
Pages
47 - 57
Database
ISI
SICI code
1388-6150(2000)63:1<47:IBAPAB>2.0.ZU;2-0
Abstract
Cyclopentenonic derivatives of prostaglandins are able to interfere at diff erent levels with virus infection but the complex mechanism of their antivi ral effect is still unresolved. As the antiviral activity was shown to be i nfluenced by the cyclopentenonic structure, the interaction with biomimetic membrane of two types of prostaglandin having different antiviral activity were studied by thermal technique and completed with epifluorescence micro scopy. The surface-pressure vs. molecular area isotherms showed an increase in the lateral packing density of the liquid-crystalline phases in the pre sence of prostaglandin A(1)-type, whereas the prostaglandin E-1-type seems to penetrate without producing any significant modifications in the molecul ar organization of the biomimetic membrane.