A 27-KDA MATRIX RECEPTOR FROM RAT-BRAIN SYNAPTOSOMES - SELECTIVE RECOGNITION OF THE ARG-GLY-ASP-SER DOMAIN AND UNIQUE RESISTANCE TO CALCIUM-DEPENDENT PROTEOLYSIS

Authors
CAPALDI D ROSARIO R ESTEBAN ET BAHR BA
Citation
D. Capaldi et al., A 27-KDA MATRIX RECEPTOR FROM RAT-BRAIN SYNAPTOSOMES - SELECTIVE RECOGNITION OF THE ARG-GLY-ASP-SER DOMAIN AND UNIQUE RESISTANCE TO CALCIUM-DEPENDENT PROTEOLYSIS, Neuroscience research, 28(3), 1997, pp. 275-279
Citations number
27
Categorie Soggetti
Neurosciences
Journal title
Neuroscience research → ACNP
ISSN journal
01680102
Volume
28
Issue
3
Year of publication
1997
Pages
275 - 279
Database
ISI
SICI code
0168-0102(1997)28:3<275:A2MRFR>2.0.ZU;2-7
Abstract
A 27-kDa protein from adult rat brain synaptosomes was purified by mat rix-affinity chromatography. The matrix receptor interacted with the A rg-Gly-Asp-Ser sequence recognized by integrin-type adhesion molecules , and was labeled by integrin antibodies. Levels of the 27-kDa species in brain membranes were unaffected by proteolysis, however, conventio nal integrin subunits exhibited robust degradation. This unique resist ance to proteolysis may allow the new matrix receptor to contribute to the stability of synaptic contacts. (C) 1997 Elsevier Science Ireland Ltd.