POSTOPERATIVE BRACHYTHERAPY - A PROGNOSTIC FACTOR FOR LOCAL-CONTROL IN EPIDERMOID CARCINOMAS OF THE MOUTH FLOOR

The aim of this study was to analyse the role of post-operative brachy therapy (BT) in a group of patients with a high risk of local relapse (positive or narrow surgical margins) for squamous cell carcinoma of t he mouth floor (SCCFM). A comparison with post-operative external beam irradiation (EBI) in a group of patients with standard risk of local relapse for SCCFM with free margins is performed to estimate the benef it of BT, From 1979 to 1992, an initial group of 32 patients with SCCF M (12, T1-2; 20, T3-4 x) received an Ir 192 low dose rate BT using pla stic tubes (+ EBT for 20 patients) after surgery with positive or clos e margins, BT was applied in one or tao planes to the surgical scar. T he mean dose of BT was 57 Gy (range: 50-60) for exclusive BT and 22 Gy (range: 15-30) when a boost was applied (mean EBI dose = 50 Gy). Duri ng the same period, 36 patients had post-operative external irradiatio n alone after satisfactory surgical resection. Excluding the post-oper ative margin, these two groups were comparable for other prognostic fa ctors, The mean follow-up was 46 months (range: 5-145) with a minimum follow-up of 2 years, For BT and EBI groups, the 5-year results (Kapla n-Meier) were, respectively, overall survival 62% and 43%, local contr ol 81% and 60% (P=0.09) (log-rank) and severe complications 4/32 and 1 /36, Post-operative BT achieves good local control for patients with n arrow or positive margins by increasing the dose to the surgical scar, with good tolerance, Given these encouraging results, we confirm this treatment for these patients.