LONG-TERM COMPLETE REMISSION OF MELANOMA LIVER METASTASES AFTER INTERMITTENT INTRAARTERIAL CISPLATIN CHEMOTHERAPY AND SURGERY

This paper presents the case of a female patient with liver metastases of a malignant melanoma showing complete remission after 10 courses o f regional, intra-arterial chemotherapy with cisplatin. The drug was a dministered as continuous infusion for 5 days. The daily dosage amount ed to 30 mg/m(2). The interval between courses was 6 weeks, Nausea and vomiting were seen after each course, while pathological serum creati nine levels only appeared after the eighth course, The only lesion in the liver still visible on CT scan after chemotherapy was removed by l eft hemihepatectomy. Meticulous histological examination revealed a bi g focus of necrotic tissue without any tumour cells. At the time of pu blication the patient is alive and disease-free over 9 gears later.