A general [3+2+1] annulation strategy for the preparation of pyridine N-oxides

Authors
Davies, IW Marcoux, JF Reider, PJ
Citation
Iw. Davies et al., A general [3+2+1] annulation strategy for the preparation of pyridine N-oxides, ORG LETT, 3(2), 2001, pp. 209-211
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
2
Year of publication
2001
Pages
209 - 211
Database
ISI
SICI code
1523-7060(20010125)3:2<209:AG[ASF>2.0.ZU;2-Q
Abstract
[GRAPHICS] Stabilized ketone, aldehyde, and ester enolates react with vinamidinium hex afluorophosphate salts and hydroxylamine hydrochloride to give access to th e corresponding pyridine N-oxides, The annulation reactions proceed in good to excellent yields with vinamidinium salts with a range of beta -substitu ents (R-3 = halo, aryl, nitro, trifluoromethyl).