Alkyne cross metathesis reactions of extended scope

Authors
Furstner, A Mathes, C
Citation
A. Furstner et C. Mathes, Alkyne cross metathesis reactions of extended scope, ORG LETT, 3(2), 2001, pp. 221-223
Citations number
32
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
2
Year of publication
2001
Pages
221 - 223
Database
ISI
SICI code
1523-7060(20010125)3:2<221:ACMROE>2.0.ZU;2-B
Abstract
[GRAPHICS] A catalyst formed in situ from Mo[N(t-Bu)(Ar)](3) 1 (Ar = 3,5-dimethylpheny l) and CH2Cl2 in toluene effects cross metathesis reactions of functionaliz ed alkynes that are beyond reach of more traditional promoters. An applicat ion to the synthesis of prostaglandin E-2 (PGE(2)) 19 and the acetylated PG E derivative 18b shows the compatibility of this method with sensitive subs trates.