General synthetic route to chiral flexible biphenylphosphine ligands: The use of a chiral additive enables the preparation and observation of metal complexes incorporating the enantiopure form
K. Mikami et al., General synthetic route to chiral flexible biphenylphosphine ligands: The use of a chiral additive enables the preparation and observation of metal complexes incorporating the enantiopure form, ORG LETT, 3(2), 2001, pp. 243-245
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The enantio- and diastereomerically pure metal complex of a chirally flexib
le BIPHEP ligand is obtained through enantiomer-selective coordination of a
BIPHEP-RU complex with enantiopure 3,3'-dimethyldiaminobinaphthyl, DM-DBN,
followed by epimerization of the remaining BIPHEP-RU enantiomer to complex
with DM-DABN. Thus, an efficient and general synthetic route to a variety
of substituted BIPHEP ligands from biphenol and observation of the enantiom
erically pure BIPHEP ligands in their Ru(II) complexes are described.