Candelalides A-C: Novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3

Authors
Singh, SB Zink, DL Dombrowski, AW Dezeny, G Bills, GF Felix, JP Slaughter, RS Goetz, MA
Citation
Sb. Singh et al., Candelalides A-C: Novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3, ORG LETT, 3(2), 2001, pp. 247-250
Citations number
10
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
2
Year of publication
2001
Pages
247 - 250
Database
ISI
SICI code
1523-7060(20010125)3:2<247:CANDPF>2.0.ZU;2-3
Abstract
[GRAPHICS] Blockers of the voltage gated potassium channel Kv1,3 are potential immunos uppressants. Candelalides A-C are three novel diterpenoid pyrones that bloc k this channel. The structure, stereochemistry, and activity against Kv1,3 are described.