An expedient method for resolution of 3-amino-3-(3 '-pyridyl)propionic acid and related compounds

Authors
Boesch, H Cesco-Cancian, S Hecker, LR Hoekstra, WJ Justus, M Maryanoff, CA Scott, L Shah, RD Solms, G Sorgi, KL Stefanick, SM Thurnheer, U Villani, FJ Walker, DG
Citation
H. Boesch et al., An expedient method for resolution of 3-amino-3-(3 '-pyridyl)propionic acid and related compounds, ORG PROC R, 5(1), 2001, pp. 23-27
Citations number
21
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC PROCESS RESEARCH & DEVELOPMENT
ISSN journal
10836160 → ACNP
Volume
5
Issue
1
Year of publication
2001
Pages
23 - 27
Database
ISI
SICI code
1083-6160(200101/02)5:1<23:AEMFRO>2.0.ZU;2-J
Abstract
Preparation of methyl (S)-3-amino-3-(3'-pyridyl)propionate dihydrochloride in high enantiomeric purity by selective crystallization of a diastereomeri c salt of a carboxylic add precursor (N-BOC-protected) with (1R,2S)-(-)-eph edrine is described. Further demonstration of the usefulness of this proced ure to resolve other 3-amino-3-[(substituted)pyridyl]propionic acids is als o described.