The emergence of Phanerozoic global diversity as a central theme of investi
gation has resulted from a confluence of factors, including the assembly by
several researchers of global taxonomic databases; the advent of computers
, which permitted construction and analysis of global Phanerozoic diversity
trajectories; and the recognition that Phanerozoic diversity trends are im
portant bellwethers of the evolutionary processes that cause biotic transit
ions. Despite the enormous progress in the measurement and interpretation o
f Phanerozoic diversity over the past quarter century, much of which has be
en reported in Paleobiology, these studies have collectively generated at l
east as many new questions as they have answered-arguably the mark of an ar
ea of inquiry that continues to be vital. In this essay, I discuss several
outstanding issues in the investigation of Phanerozoic diversity, ranging f
rom the viability of literature-derived databases for investigating global
diversity trends, to the biological significance of the myriad biotic trans
itions that have taken place throughout the Phanerozoic.