The use of intravenous immunoglobulin in sine causa or alloimmune recurrent spontaneous abortion (RSA)

Background. Recurrent spontaneous abortion (RSA) has an incidence of 0.5 % -1 %, It is thought that immune reaction disorders in the mother may evolve in unexplained RSA, which has a higher incidence In women over 40 years ol d. Methods. Twenty-three patients with recurrent spontaneous abortion of unkno wn origin and two autoimmune cases were treated with intravenous specific i mmunoglobulins at the 5th-6th week of pregnancy and fifteen days later. Results, After treatment, nineteen patients brought their pregnancy to term , five aborted, one is pregnant at present. Conclusions. The use of immunoglobulins seems to be efficacious in recurren t spontaneous abortion of unknown origin. Our results support the theory th at this treatment is able to passively transfer the sparking off factor tha t allows the pregnancy to evolve.