The kallikrein-kininogen-kinin system: lessons from the quantification of endogenous kinins

Authors
Blais, C Marceau, F Rouleau, JL Adam, A
Citation
C. Blais et al., The kallikrein-kininogen-kinin system: lessons from the quantification of endogenous kinins, PEPTIDES, 21(12), 2000, pp. 1903-1940
Citations number
425
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PEPTIDES
ISSN journal
01969781 → ACNP
Volume
21
Issue
12
Year of publication
2000
Pages
1903 - 1940
Database
ISI
SICI code
0196-9781(200012)21:12<1903:TKSLFT>2.0.ZU;2-O
Abstract
The purpose of the present review is to describe the place of endogenous ki nins, mainly bradykinin (BK) and des-Arg(9)-BK in the kallikrein-kininogen- kinin system, to review and compare the different analytical methods report ed for the assessment of endogenous kinins, to explain the difficulties and the pitfalls for their quantifications in biologic samples and finally to see how the results obtained by these methods could complement and extend t he pharmacological evidence of their pathophysiological role. (C) 2000 Else vier Science Inc. All rights reserved.