The syndrome of neuromyotonia produces muscle stiffness, cramps, and f
requently, excessive sweating. Most cases are idiopathic, but some are
associated with neoplasms, especially immune cell cancers. Voltage-ga
ted potassium channels may be the target of an autoantibody attack in
idiopathic generalized neuromyotonia (Isaacs' syndrome). The cases ass
ociated with neoplasms may also have an autoimmune etiology. We report
the first case of neuromyotonia as the presenting feature of Hodgkin'
s lymphoma and propose a paraneoplastic mechanism that would link the
purported autoimmune etiology in Isaacs' syndrome with the cancer-asso
ciated cases.