A CASE OF HODGKINS-LYMPHOMA PRODUCING NEUROMYOTONIA

Citation
Jb. Caress et al., A CASE OF HODGKINS-LYMPHOMA PRODUCING NEUROMYOTONIA, Neurology, 49(1), 1997, pp. 258-259
Citations number
12
Categorie Soggetti
Clinical Neurology
Journal title
ISSN journal
00283878
Volume
49
Issue
1
Year of publication
1997
Pages
258 - 259
Database
ISI
SICI code
0028-3878(1997)49:1<258:ACOHPN>2.0.ZU;2-6
Abstract
The syndrome of neuromyotonia produces muscle stiffness, cramps, and f requently, excessive sweating. Most cases are idiopathic, but some are associated with neoplasms, especially immune cell cancers. Voltage-ga ted potassium channels may be the target of an autoantibody attack in idiopathic generalized neuromyotonia (Isaacs' syndrome). The cases ass ociated with neoplasms may also have an autoimmune etiology. We report the first case of neuromyotonia as the presenting feature of Hodgkin' s lymphoma and propose a paraneoplastic mechanism that would link the purported autoimmune etiology in Isaacs' syndrome with the cancer-asso ciated cases.