D. Zheng et al., Skeletal muscle kinetics of propofol in anaesthetized sheep: effect of altered muscle blood flow, XENOBIOTICA, 30(11), 2000, pp. 1079-1090
1. The kinetics of propofol were studied in vivo in a skeletal muscle bed o
f the hindlimb of the anaesthetized sheep at normal and low rates of blood
flow.
2. Propofol kinetics in muscle were determined during and after a 20-min i.
v. infusion of propofol (10 mg min(-1)) via paired arteriofemoral venous bl
ood sampling. One-and-a-half hours later, the study was repeated but with a
concurrent left femoral artery infusion of adrenaline (0.004 mg min(-1)) t
o lower the muscle blood flow by vasoconstriction.
3. Muscle blood flow in the low flow state was 28% of that in the normal st
ate. The kinetics were poorly described by a single flow-limited compartmen
t model, but were better described by a model with a flow-limited component
and a deeper distribution component. There were no significant differences
in muscle retention of propofol between normal and low flow states.
4. There was an apparent arteriovenous shunt of similar to 24% of total mus
cle blood flow for the low flow slate, but not for the normal blood flow st
ate.