Littoral cell angioma associated with portal hypertension and resected colon cancer

Littoral cell angioma (LCA) is a rare vascular tumor of the spleen with an unknown etiology and unclear natural history. An association with synchrono us malignancy has been described. We report the case of a 54-year-old woman who had progressive splenomegaly over 3 years following resection of a col on adenocarcinoma. The splenomegaly was associated with portal hypertension and severe thrombocytopenia. Splenectomy was performed, and the histologic and immunocytochemical features of the spleen specimen were consistent wit h LCA. The relationship between LCA and malignancy is reviewed. Copyright ( C) 2001 S. Karger AG, Basel.