Aerobic capacity in adults with various congenital heart diseases

As an increasing number of patients with congenital heart disease reach adu lthood, more information is needed regarding outcomes. The first signs of i mpaired heart function may appear during exercise testing. The aim of the p resent study was to establish mean values for maximal oxygen uptake in adul ts with various congenital heart diseases. Patients from 6 major diagnostic groups were identified, including patients with atrial septal defect (ASD, n = 93), transposition of the greet arteries corrected with the Mustard pr ocedure (n = 84), congenitally corrected transposition of the great arterie s (CCTGA, n = 41), Tetralogy of Fallot (n = 168), Ebstein's anomaly (n = 37 ), and Modified Fontan procedure (n = 52). Diminished maximal oxygen uptake was found in all diagnostic groups across age compared with healthy subjec ts. A significant decrease in maximal oxygen uptake with aging was found in those with ASD (p <0.0001), CCTGA (p = 0.01), and Tetralogy of Fallot (p < 0.0001). There was no significant decline, however, in Ebstein's anomaly (p = 0.270), Fontan procedure (p = 0.182), and in the Mustard patients (p = 0 .188). All patients achieved significantly lower heart rates than predicted (mean for all groups, p <0.0001). Forced vital capacity values (3.51 L, me an SD +/- 1.02) were lower than predicted values (4.10 L, mean SD +/- 0.90, p <0.0001) for all patients groups except those with ASD. Mean values, how ever, were within the accepted 20% range of variance. This study showed dim inished aerobic capacity in all diagnostic groups when compared with a heal thy population. The maximal oxygen uptake values across age groups can be u sed as reference values in patients with similar diagnoses and as the basis for further research. (C) 2001 by Excerpta Medica, Inc.