Fibrinogen response with simvastatin versus atorvastatin in familial hypercholesterolemia

Authors
Wierzbicki, AS Lumb, PJ Chik, G Crook, MA
Citation
As. Wierzbicki et al., Fibrinogen response with simvastatin versus atorvastatin in familial hypercholesterolemia, AM J CARD, 87(3), 2001, pp. 338
Citations number
20
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF CARDIOLOGY
ISSN journal
00029149 → ACNP
Volume
87
Issue
3
Year of publication
2001
Database
ISI
SICI code
0002-9149(20010201)87:3<338:FRWSVA>2.0.ZU;2-2
Abstract
The clinical and biochemical determinants of the fibrinogen response to sim vastatin or atorvastatin therapy were assessed in 130 patients with severe polygenic or familial hypercholesterolemia treated in a randomized open-tri al format design. Hyperfibrinogenemia was associated with atorvastatin, bas eline fibrinogen, and initial concentration and change in concentration of apolipoprotein B or low-density lipoprotein cholesterol.