Renal transplantation after Streptococcus pneumoniae-associated hemolytic uremic syndrome

Citation
Dj. Krysan et Jt. Flynn, Renal transplantation after Streptococcus pneumoniae-associated hemolytic uremic syndrome, AM J KIDNEY, 37(2), 2001, pp. NIL_83-NIL_90
Citations number
36
Categorie Soggetti
Urology & Nephrology
Journal title
AMERICAN JOURNAL OF KIDNEY DISEASES
ISSN journal
02726386 → ACNP
Volume
37
Issue
2
Year of publication
2001
Pages
NIL_83 - NIL_90
Database
ISI
SICI code
0272-6386(200102)37:2<NIL_83:RTASPH>2.0.ZU;2-F
Abstract
Of the several causes of nondiarrheal hemolytic uremic syndrome (HUS), infe ction with Streptococcus pneumoniae is infrequent, but important, because o f its unique pathogenesis. A comprehensive literature review found 37 well- documented cases of S pneumoniae-associated HUS (SP-HUS), only 2 of which p rogressed to end-stags renal disease (ESRD). We report the third such child , and the first to receive a renal transplant following SP-HUS. Her course illustrates several unique characteristics of SP-HUS common to previous pat ients reported in the literature, including a greater duration of oligoanur ia compared with cases not progressing to ESRD, the significant adverse eff ect of unwashed blood products, and a possible influence of female gender o n outcome. Clinicians caring for children with SP-HUS should be aware of th ese differences and modify therapy appropriately to avoid known risk factor s for poor outcome, specifically the use of unwashed blood products. (C) 20 01 by the National Kidney Foundation, Inc.