Jo. Karonen et al., Evolution of MR contrast enhancement patterns during the first week after acute ischemic stroke, AM J NEUROR, 22(1), 2001, pp. 103-111
Citations number
28
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Neurosciences & Behavoir
BACKGROUND AND PURPOSE: Intravascular and parenchymal enhancement have been
detected with contrast-enhanced T1-weighted MR imaging in patients with is
chemic stroke. Diffusion-weighted MR imaging depicts infarct within minutes
after the onset of symptoms. The aims of this study were to study the diff
erent MR enhancement findings during the first week after stroke and to asc
ertain whether the presence of intravascular enhancement over a larger area
than the infarct on diffusion-weighted images on day 1 is able to predict
substantial infarct growth during the first week.
METHODS: Forty-eight patients were imaged on the first and second days and
again 1 week after the onset of ischemic stroke. T1-weighted spin-echo imag
ing was performed before and after a 0.2 mmol/kg bolus of gadolinium chelat
e, Diffusion-weighted imaging was performed at the same slice positions. En
hancement findings were categorized as intravascular and parenchymal, with
further categorization of parenchymal enhancement as cortical, subcortical,
and deep; these findings were then compared with diffusion-weighted imagin
g findings.
RESULTS: Intravascular enhancement in the infarcted area was detected on da
y 1 in 78% of the cases, on day 2 in 78% of the cases, and at 1 week in 30%
of the cases. Parenchymal enhancement was detected in 26%, 56%, and 100% o
f the cases, respectively. Intravascular enhancement over a larger area tha
n the infarct on diffusion-weighted images on day 1 was not associated with
the extent of infarct growth,
CONCLUSION: Detection of different patterns of contrast enhancement can hel
p in determining the age of infarct, Parenchymal enhancement may be intense
and can cause diagnostic uncertainty in cases in which the clinical histor
y is obscure.