Acute measles gastric infection

We describe the case of a 44-year-old man who was referred for gastroscopy because of abdominal pain. During endoscopy, inflammatory changes of the an trum and corpus mucosa were clearly visible, and biopsy samples from the an trum and corpus mucosa were taken. At histology, routine hematoxylin and eo sin staining showed characteristics indicative of so-called ex Helicobacter pylori-gastritis that had developed after antibiotic treatment 2 years ago . Additional large bizarre inclusion bodies and clusters of multinucleated giant cells were located in the surface epithelium and within the lamina pr opria. These giant cells had an appearance similar to that of Warthin-Finke ldey cells, which can be found during the prodromal phase of measles infect ion. Anti-measles virus immunochemistry showed a strong positivity for meas les virus antigen within the giant cells. Based on these results, the final diagnosis of morbilliform gastritis was made. To our knowledge no case of measles gastritis has been described in the literature. Our case report con firms the systemic character of measles virus infection and confirms that m easles viral replication can involve the gastric mucosa in addition to the conjunctiva, lung, and intestina.