Microchip-based synthesis and analysis: Control of multicomponent reactionproducts and intermediates

A miniaturised-SYNthesis and Total Analysis System (mu SYNTAS) was used for the solution-phase synthesis and on-line analysis (TOF-MS) of Ugi multicom ponent reaction (MCR) products. This approach provides an unusually high de gree of control of the MCR and delivers detailed, novel information on reac tion intermediates in real-time. Specifically, the Ugi 4 component condensa tion (4CC) involving the reaction of an amine, acid, aldehyde and isocyanid e species was performed at room temperature in a controllable fashion. Furt hermore, observation of the nitrilium intermediate, cyclohexyl(2-piperidin- 1-ylethylidyne)ammonium chloride, is presented for the first time.