In this study, the case has been reported of a sctotal tumor in a 50-year o
ld male admitted with a large warty lesion at the base of the scrotum which
resembled a giant condyloma accuminatum (Buschk-Lowenstein tumor). The HIV
serology was negative, but the papillomavirus findings were positive. A co
mplete resection of the tumor was performed. The histological findings conf
irmed the diagnosis of condyloma accuminatum without evidence of degenerati
ve development into a squamous cell carcinoma. The clinical course was favo
rable, and no local recurrence was observed at 16 months follow-up. The pro
blems that are frequently encountered in the diagnosis and therapy connecte
d with this type of tumor have also been discussed. (C) 2001 Editions scien
tifiques et medicales Elsevier SAS.