Prognostic factors and long-term survival in 585 patients with metastatic breast cancer treated with epirubicin-based chemotherapy

Background: Analysis of prognostic factors in patients with metastatic brea st cancer treated with epirubicin-based chemotherapy. Patients and methods: Data from 469 patients treated with epirubicin-based chemotherapy for metastatic breast cancer were used. Prognostic factors wer e identified (Cox multivariate analysis). A prognostic index was compiled a nd risk groups were established accordingly. The applicability of the index was investigated in a series of 116 patients. Results: The prognostic factors identified were: liver, pleural, soft tissu e, lung and bone metastases, performance status >2, advancing age, abnormal elevation of serum lactate dehydrogenase and negative/unknown oestrogen re ceptor status. Four risk groups were established: good, intermediate I, int ermediate II and poor. The median and five-year survivals in percentage wer e: good: 34 months (26%); intermediate I: 19 months (6%); intermediate II: 12 months (0%); poor: 7 months (1%). The corresponding values in the applic ability group were: 32 months (23%); 28 months (22%); 18 months (5%); and 6 months (0%). Conclusions: It is more the number and impact on the organs involved, that predict the patients' survival. The construction of a prognostic index coul d be helpful in assessing the outlook for patients, especially the quite dr amatic difference in long-term survival between the good and poor risk pati ents.