Perilesional IL-2 treatment of a VX2 head-and-neck cancer model can inducea systemic anti-tumour activity

Background: Head-and-neck cancer is associated with impaired cell-mediated immune reactivity. A rabbit model with VX2 Squamous Cell Carcinoma transpla nted into both auricles was used to test the effects of a regimen for local Interleukin 2 (IL-2) therapy, optimal in murine tumour models. Materials a nd Methods: Peri-tumoural IL-2 treatment star fed 2 and consisted of wizen one of the tumours exceeded 2 cm 100,000 or 300,000 Chiron Units IL-2 or on ly solvent during 5 consecutive days. Results: In 4 out of 12 (33%) rabbits the treated primary tumours regressed completely, simultaneously with the non-treated contra-lateral rumours. Also metastases in draining lymph nodes of both treated and untreated primary tumours regressed in three of these animals. Tumour cells injected in the cured animals were rejected. The hist ology of the regressing tumours in cured cases showed an active granulomato us reaction with a histiocytic response, splitting rip of tumour islands, a nd fibrinoid obstruction of blood vessels. Conclusion: These findings showe d local and systemic therapeutic effects of this local IL-2 regimen in a VX 2 head-and-neck cancer model.