FOCAL MESANGIAL-SCLEROSING GLOMERULONEPHRITIS AND ACUTE-SPONTANEOUS INFECTIOUS CANINE HEPATITIS - STRUCTURAL, IMMUNOHISTOCHEMICAL AND SUBCELLULAR STUDIES

Authors
HERVAS J GOMEZVILLAMANDOS JC PEREZ J CARRASCO L SIERRA MA
Citation
J. Hervas et al., FOCAL MESANGIAL-SCLEROSING GLOMERULONEPHRITIS AND ACUTE-SPONTANEOUS INFECTIOUS CANINE HEPATITIS - STRUCTURAL, IMMUNOHISTOCHEMICAL AND SUBCELLULAR STUDIES, Veterinary immunology and immunopathology, 57(1-2), 1997, pp. 25-32
Citations number
17
Categorie Soggetti
Immunology,"Veterinary Sciences
Journal title
Veterinary immunology and immunopathology → ACNP
ISSN journal
01652427
Volume
57
Issue
1-2
Year of publication
1997
Pages
25 - 32
Database
ISI
SICI code
0165-2427(1997)57:1-2<25:FMGAAI>2.0.ZU;2-G
Abstract
The glomerular alterations observed in a dog with acute spontaneous in fectious canine hepatitis (ICH) are described, Histologic changes of t he glomeruli were enlargement of the mesangium with presence of intran uclear inclusion bodies and without proliferation of mesangial cells. Electron microscopy revealed adenovirus replication sites in glomerula r mesangial cells and in endothelial cells of glomerular capillaries, as well as a focal mesangial-sclerosing glomerulonephritis associated with electron dense deposits which were closely related with extracell ular ICH viral particles and immunohistochemically reactive for immuno globulin (Ig) G, IgA, IgM and C3c complement components. (C) 1997 Else vier Science B.V.