Stability, toxicity and cytotoxicity of a cupric complex towards cultured CaCo-2 cells

Authors
Thanh, XD Djebbar-Sid, S Benali-Baitich, O Pehu, G Khan, MA Bouet, G
Citation
Xd. Thanh et al., Stability, toxicity and cytotoxicity of a cupric complex towards cultured CaCo-2 cells, ANTICANC R, 20(6B), 2000, pp. 4639-4642
Citations number
7
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ANTICANCER RESEARCH
ISSN journal
02507005 → ACNP
Volume
20
Issue
6B
Year of publication
2000
Pages
4639 - 4642
Database
ISI
SICI code
0250-7005(200011/12)20:6B<4639:STACOA>2.0.ZU;2-A
Abstract
The human colon adenocarcinoma-derived cell line CaCo-2 was used as a model system to study the effects of copper (II), tetradentate N-alkyl ligand (H 2L) and their complex. The stimulatory effect of the complex was obtained w ith lower concentrations from 10(-7) to 10(-17) mol.L-1 while inhibiting ef fects occur from 10(-4) to 10(-6) mol.L-1. According to this study, copper (II) and free ligand were toxic for cultured cells. Our data suggested that the complex, according to our toxicity assays in mice, could be used as an antimitotic agent.