Uptake of the Re-188(V)-DMSA complex by cervical carcinoma cells in nude mice: pharmacokinetics and dosimetry

The uptake of the rhenium-188 (Re-188(V)-DMSA) complex of dimercaptosuccini c acid by cervical carcinoma cells in nude mice was evaluated. The pharmaco kinetics and dosimetry calculations in normal rats were also evaluated. The images obtained in mice did not show significant accumulation in metabolic organs and the biodistribution studies showed that 3.52 +/- 0.76% of the i njected activity per gram (n = 4) was taken up by the tumor. This percentag e produces a cumulated activity of 35.63 +/- 8.40 MBq h and an equivalent d ose per injected activity of 260 +/- 8.91 mSv/MBq. Pharmacokinetics and dos imetry of the Re-188(V)-DMSA complex indicate that this radiopharmaceutical could be evaluated in patients with soft tissue tumors, since the risk of radiation damage to the kidney or red bone marrow could not be an obstacle for its application in therapeutic nuclear medicine. (C) 2001 Elsevier Scie nce Ltd. All rights reserved.