Labelling of Re-ABP with Re-188 for bone pain palliation

Etidronate and medronate have been labelled with technetium-99m (Tc-99m-HED P, Tc-99m-MDP) for bone scanning and, with rhenium-188 (Re-188-HEDP) to pal liate the pain resulting from bone metastases. The objective of this study was to label alendronate, ABP, a new bisphosphonate, with SnF2-reduced-Re-1 88. The reagents for the 5 mg ABP kit were SnF2, KReO4 and gentisic acid at acid pH. The chemical, spectroscopic and microscopic characteristics, qual ity control, rat bone uptake of [Re-188]Re-ABP and similarities with Tc-99m -ABP are presented. We conclude that this is a promising new radiopharmaceu tical for bone metastases pain palliation. (C) 2001 Elsevier Science Ltd. A ll rights reserved.