Two observations of the complex interstellar absorption-line profiles in th
e UV spectrum of CPD -59 degrees 2603, obtained 22 months apart in the R si
milar to 110,000 mode of the Space Telescope Imaging Spectrograph on the Hu
bble Space Telescope, reveal substantial variations in the intensities of s
everal high-velocity components, including the virtual disappearance of one
of them. These are the first observations of interstellar temporal variati
ons in dominant ions to our knowledge. The most probable interpretation is
motion across the line of sight of discrete absorbing features in the near
foreground of the O-type star, within the Carina Nebula. Ground-based surve
y data also indicate that the extreme interstellar profiles throughout this
region originate relatively near the most massive stars, suggesting an ori
gin related to their stellar winds. The morphological similarity of these p
rofiles to a low-ionization, narrow-line system in a quasi-stellar object (
QSO) spectrum is pointed out. Time variability may provide a critical test
among different interpretations of such QSO systems.