Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids

Authors
Duits, LA Rademaker, M Ravensbergen, B van Sterkenburg, MAJA van Strijen, E Hiemstra, PS Nibbering, PH
Citation
La. Duits et al., Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids, BIOC BIOP R, 280(2), 2001, pp. 522-525
Citations number
25
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
280
Issue
2
Year of publication
2001
Pages
522 - 525
Database
ISI
SICI code
0006-291X(20010119)280:2<522:IOHBNH>2.0.ZU;2-R
Abstract
Intensive use of corticosteroids may be accompanied by increased susceptibi lity to infections; hence, we investigated the effects of dexamethasone on the expression of antimicrobial peptides, termed human beta -defensins (hBD ), by cultured bronchial epithelial cells and mononuclear phagocytes. The r esults revealed that dexamethasone inhibited the (stimulated) expression of mRNA for hBD-3, but not hBD-1 and hBD-2 by these epithelial cells. Dexamet hasone did not affect the (stimulated) mRNA expression of hBD-1 and hBD-2 b y mononuclear phagocytes, whereas these cells did not express hBD-3 mRNA. ( C) 2001 Academic Press.