A NEW 1,2,3-TRIAZOLO[1,2]BENZODIAZEPINE RING-SYSTEM

Authors
KNIGHT DW LITTLE PB
Citation
Dw. Knight et Pb. Little, A NEW 1,2,3-TRIAZOLO[1,2]BENZODIAZEPINE RING-SYSTEM, Tetrahedron letters, 38(28), 1997, pp. 5037-5040
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
28
Year of publication
1997
Pages
5037 - 5040
Database
ISI
SICI code
0040-4039(1997)38:28<5037:AN1R>2.0.ZU;2-W
Abstract
Dianion 2 derived from N-Boc-aminobenzotriazole 1 condenses in a [1.2] -fashion with alpha,beta-unsaturated aldehydes; subsequent oxidation o f the resulting allylic alcohols 7 using manganese(IV) oxide or, less effectively, treatment of the derived acetates 10 with Pd(0), results in direct formation of the novel triazolo[1,2]benzodiazepines 9 and 11 by intramolecular addition of the pendant amino group. (C) 1997 Elsev ier Science Ltd.