Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP

Authors
Harrison, JA Kartha, KPR Turnbull, WB Scheuerl, SL Naismith, JH Schenkman, S Field, RA
Citation
Ja. Harrison et al., Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP, BIOORG MED, 11(2), 2001, pp. 141-144
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
141 - 144
Database
ISI
SICI code
0960-894X(20010122)11:2<141:HASAOT>2.0.ZU;2-Z
Abstract
NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to ac t as a substrate for the hydrolase and transferase activities of Trypanosom a cruzi trans-sialidase have been investigated. The turn-over of this compo und shows marked differences from the behaviour of NeuAc-MU. In addition, d istinct differences in the action of T. cruzi trans-sialidase and Clostridi um perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were appar ent. (C) 2001 Elsevier Science Ltd. All rights reserved.