Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors

Authors
Kaila, N Thomas, BE Thakker, P Alvarez, JC Camphausen, RT Crommie, D
Citation
N. Kaila et al., Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors, BIOORG MED, 11(2), 2001, pp. 151-155
Citations number
40
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
151 - 155
Database
ISI
SICI code
0960-894X(20010122)11:2<151:DASOSL>2.0.ZU;2-E
Abstract
The design and synthesis of novel beta -C-mannosides that inhibit the bindi ng of sialyl Lewis x to E-selectin are described. Compounds that contained a phenyl substituent at the C-6 position were found to have increased poten cy. (C) 2001 Elsevier Science Ltd. All rights reserved.