3,28-di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents

Authors
Kashiwada, Y Chiyo, J Ikeshiro, Y Nagao, T Okabe, H Cosentino, LM Fowke, K Lee, KH
Citation
Y. Kashiwada et al., 3,28-di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents, BIOORG MED, 11(2), 2001, pp. 183-185
Citations number
5
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
183 - 185
Database
ISI
SICI code
0960-894X(20010122)11:2<183:3IAAA>2.0.ZU;2-C
Abstract
Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and eval uated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cell s. 3-O-(3', 3'-Dimethylsuccinyl)-28-O-(2", 2"-dimethylsuccinyl)-betulin (11 ) was the most potent anti-HIV compound with an EC50 value of 0.00087 muM a nd a TI value of 42,400. (C) 2001 Elsevier Science Ltd. All rights reserved .