Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K

Authors
Fenwick, AE Garnier, B Gribble, AD Ife, RJ Rawlings, AD Witherington, J
Citation
Ae. Fenwick et al., Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K, BIOORG MED, 11(2), 2001, pp. 195-198
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
195 - 198
Database
ISI
SICI code
0960-894X(20010122)11:2<195:SSOCAI>2.0.ZU;2-X
Abstract
Using solid-phase synthesis, a library of novel cyclic alkoxyketones has be en constructed which show strong inhibitory activity against the cysteine p rotease, cathepsin K (EC 3.4.22.38). (C) 2001 Published by Elsevier Science Ltd.