Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K

Authors
Fenwick, AE Gribble, AD Ife, RJ Stevens, N Witherington, J
Citation
Ae. Fenwick et al., Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K, BIOORG MED, 11(2), 2001, pp. 199-202
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
199 - 202
Database
ISI
SICI code
0960-894X(20010122)11:2<199:DSAACS>2.0.ZU;2-W
Abstract
The diastereoselective synthesis of a novel class of cathepsin K inhibitors together with their cathepsin K affinity and stability towards aqueous buf fer is reported. (C) 2001 Published by Elsevier Science Ltd.