Dimeric beta-turn peptidomimetics as ligands for the neurotropin receptor TrkC

Authors
Zhang, AJ Khare, S Gokulan, K Linthicum, DS Burgess, K
Citation
Aj. Zhang et al., Dimeric beta-turn peptidomimetics as ligands for the neurotropin receptor TrkC, BIOORG MED, 11(2), 2001, pp. 207-210
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
207 - 210
Database
ISI
SICI code
0960-894X(20010122)11:2<207:DBPALF>2.0.ZU;2-F
Abstract
Twelve dimeric peptidomimetics 1 were prepared via a divergent-convergent s trategy. These peptidomimetics incorporated the same amino acids as i+1 and i+2 residues in key beta -turns of the neurotrophin NT-3. Cytosensor micro physiometry was used to gauge the effects of the dimers 1 on cells that ove rexpress the NT-3 receptor, TrkC. Increases in extracellular acidification rates were observed for some monomers 3, but the active dimers gave greater effects. (C) 2001 Elsevier Science Ltd. All rights reserved.